Background. Complex regional pain syndrome (CRPS) is a rare but debilitating pain disorder. Although the exact pathophysiology\nof CRPS is not fully understood, central and peripheral mechanisms might be involved in the development of this disorder.\nTo reveal the central mechanism of CRPS, we conducted a proteomic analysis of rat cerebrum using the chronic postischemia\npain (CPIP) model, a novel experimental model of CRPS. Materials and Methods. After generating the CPIP animal model, we\nperformed a proteomic analysis of the rat cerebrum using a multidimensional protein identification technology, and screened the\nproteins differentially expressed between the CPIP and control groups. Results. A total of 155 proteins were differentially expressed\nbetween the CPIP and control groups: 125 increased and 30 decreased; expressions of proteins related to cell signaling, synaptic\nplasticity, regulation of cell proliferation, and cytoskeletal formation were increased in the CPIP group. However, proenkephalin A,\ncereblon, and neuroserpin were decreased in CPIP group. Conclusion. Altered expression of cerebral proteins in the CPIP model\nindicates cerebral involvement in the pathogenesis of CRPS. Further study is required to elucidate the roles of these proteins in the\ndevelopment and maintenance of CRPS.
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